TBC1D30

Across TCGA patient cohorts, TBC1D30 mutation is significantly associated with the RNA expression of many other genes, with 851 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D30-associated genes across cancer lineages are OR9K2, FAM219B, and C14orf28. Each is linked with TBC1D30 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D30-to-partner and partner-to-TBC1D30 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9K2 grouped by TBC1D30-low versus TBC1D30-high in SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D30→partner) and Y-score (partner→TBC1D30) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	OR9K2 →	+0.147	+4.437	<.001	.001	3	1
UCEC	FAM219B →	+0.457	+3.332	.006	.005	3	1
UCEC	C14orf28 →	+0.363	+2.332	.005	.003	3	1
UCEC	FCER1A →	-0.767	-3.560	.004	.002	3	1
UCEC	ZADH2 →	+0.586	+2.321	.002	.006	3	1
UCEC	SLC36A4 →	+0.689	+2.321	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 851 associations by consensus.

OR9K2 by TBC1D30 expression — SCLC

Explore this box plot interactively →