TBC1D2B

Across TCGA pan-cancer cohorts, TBC1D2B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TBC1D2B data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TBC1D2B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D2B expression acts as an unfavorable survival marker.

COAD, LSCC, and CCRCC are the cancer types where TBC1D2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.909	1.000	.010	72	view →
LSCC	DFS	Tertile	II,III,IV	0.539	0.952	.003	23	view →
CCRCC	DFS	Median	II,III,IV	0.794	0.943	.015	19	view →
PDAC	OS	Median	All	0.323	0.509	.036	6	view →
UCEC	DFS	Median	II,III,IV	0.538	0.862	.048	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TBC1D2B–COAD (DFS)

Open the COAD breakdown →