TBC1D27P

Across TCGA patient cohorts, TBC1D27P mutation is significantly associated with the RNA expression of many other genes, with 334 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D27P-associated genes across cancer lineages are GPATCH11, GBP5, and PKN3. Each is linked with TBC1D27P in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D27P-to-partner and partner-to-TBC1D27P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPATCH11 grouped by TBC1D27P-low versus TBC1D27P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D27P→partner) and Y-score (partner→TBC1D27P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GPATCH11 →	+0.472	+3.213	.004	.009	3	1
UCEC	GBP5 →	+1.472	+3.475	<.001	.002	3	1
UCEC	PKN3 →	+0.656	+3.202	.003	.009	3	1
UCEC	CD3G →	+0.873	+3.210	<.001	.009	3	1
UCEC	FCRL3 →	+0.414	+3.917	.001	<.001	3	1
UCEC	IKZF3 →	+0.967	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 334 associations by consensus.

GPATCH11 by TBC1D27P expression — UCEC

Explore this box plot interactively →