TBC1D27P

Across TCGA pan-cancer cohorts, TBC1D27P RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TBC1D27P data layer compared with 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TBC1D27P RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TBC1D27P expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where TBC1D27P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.667	0.523	<.001	139	view →
SKCM	OS	Median	All	0.434	0.268	<.001	104	view →
LUAD	OS	Tertile	All	0.880	0.760	<.001	94	view →
KIRC	DFS	Tertile	All	0.503	0.696	<.001	53	view →
ESCA	DFS	Quartile	II,III,IV	0.740	0.453	.005	33	view →
BRCA	OS	Median	III,IV	0.720	0.422	.002	23	view →
SARC	OS	Median	All	0.894	0.792	.003	20	view →
CESC	OS	Median	All	0.865	0.722	.001	18	view →
STAD	OS	Tertile	II,III,IV	0.762	0.385	.013	15	view →
READ	OS	Quartile	II,III,IV	0.818	0.445	.011	11	view →
TGCT	DFS	Median	All	0.925	0.738	.001	10	view →
DLBC	DFS	Median	All	0.629	1.000	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TBC1D27P–HNSC (DFS)

Open the HNSC breakdown →