TBC1D27P

Across TCGA patient cohorts, TBC1D27P mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D27P-associated genes across cancer lineages are Fibronectin, XBP1, and YB-1. Each is linked with TBC1D27P in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D27P-to-partner and partner-to-TBC1D27P results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by TBC1D27P-low versus TBC1D27P-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D27P→partner) and Y-score (partner→TBC1D27P) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.350	-2.312	.035	.034	3	1
UCEC	XBP1 →	-0.221	-3.000	.001	.036	3	1
UCEC	YB-1 →	-0.213	-2.999	.007	.035	3	1
UCEC	PDK1_pS241 →	+0.230	+2.335	.007	.020	2	1
UCEC	Annexin-1 →	+0.675	+3.019	.010	.019	2	1
UCEC	Bax →	+0.343	+3.009	.004	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Fibronectin by TBC1D27P expression — UCEC

Explore this box plot interactively →