TBC1D24

Across TCGA pan-cancer cohorts, TBC1D24 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated TBC1D24 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TBC1D24 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TBC1D24 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and LUAD are the cancer types where TBC1D24 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	III,IV	1.000	0.552	.002	20	view →
UCEC	DFS	Quartile	III,IV	1.000	0.409	.040	8	view →
LUAD	OS	Median	III,IV	1.000	0.770	.006	7	view →
COAD	DFS	Median	All	1.000	0.937	.048	6	view →
GBM	DFS	Tertile	All	0.874	0.708	.003	6	view →
CCRCC	DFS	Tertile	All	1.000	0.722	.027	1	view →
HNSC	OS	Median	III,IV	0.756	0.918	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

TBC1D24–PDAC (OS)

Open the PDAC breakdown →