TBC1D22B

Across TCGA patient cohorts, TBC1D22B protein abundance is significantly associated with the RNA expression of many other genes, with 9,876 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TBC1D22B-associated genes across cancer lineages are GNB3, ASCC3, and FFAR2. Each is linked with TBC1D22B in more than 3 cancer types. Because this analysis shows association rather than direction, both TBC1D22B-to-partner and partner-to-TBC1D22B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TBC1D22B versus GNB3 in HNSC, with a Pearson correlation of -0.27.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D22B→partner) and Y-score (partner→TBC1D22B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GNB3 →	-0.604	-0.217	.007	.001	3	3
BRCA	ASCC3 →	+0.475	+0.198	.004	.007	3	3
HNSC	FFAR2 →	+1.074	+0.195	.001	.007	3	3
BRCA	KLHDC4 →	-0.460	-0.233	<.001	.003	3	3
BRCA	CCDC130 →	-0.508	-0.220	.006	.004	3	3
BRCA	MAPK14 →	+0.495	+0.363	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,876 associations by consensus.

TBC1D22B vs GNB3 — HNSC

Explore this scatter interactively →