TBC1D22B

Across TCGA patient cohorts, TBC1D22B mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D22B-associated genes across cancer lineages are PCNA, JNK2, and MEK1. Each is linked with TBC1D22B in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D22B-to-partner and partner-to-TBC1D22B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by TBC1D22B-low versus TBC1D22B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D22B→partner) and Y-score (partner→TBC1D22B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.295	+1.700	.001	.044	3	2
UCEC	JNK2 →	+0.347	+3.469	<.001	.002	3	1
UCEC	MEK1 →	+0.553	+2.906	<.001	.001	2	2
UCEC	Notch1 →	+0.165	+2.469	.005	.010	3	1
UCEC	p70-S6K_pT389 →	-0.199	-3.169	.013	.018	3	1
UCEC	Stathmin →	+0.127	+2.222	.029	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PCNA by TBC1D22B expression — UCEC

Explore this box plot interactively →