TBC1D22B

Across TCGA cell cohorts, TBC1D22B RNA expression is significantly associated with the go_rna of many other GO terms, with 2,909 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D22B-associated GO terms across cancer lineages are Negative regulation of RNA export from nucleus, Regulation of RNA export from nucleus, and Protein polyubiquitination. Each is linked with TBC1D22B in more than 13 cancer types. Because this analysis shows association rather than direction, both TBC1D22B-to-partner and partner-to-TBC1D22B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA export from nucleus grouped by TBC1D22B-low versus TBC1D22B-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D22B→partner) and Y-score (partner→TBC1D22B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of RNA export from nucleus →	+0.093	+0.572	.001	<.001	3	14
BREAST	Regulation of RNA export from nucleus →	+0.120	+0.611	<.001	.001	3	13
BLOOD_Lymphoma	Protein polyubiquitination →	+0.036	+0.586	<.001	.002	3	11
LARGE_INTESTINE	Endosomal transport →	+0.054	+0.573	<.001	<.001	3	10
STOMACH	Regulation of transcription initiation by RNA polymerase II →	+0.052	+0.608	.001	.003	3	10
STOMACH	Vesicle-mediated transport to the plasma membrane →	+0.085	+0.711	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,909 associations by consensus.

Negative regulation of RNA export from nucleus by TBC1D22B expression — BREAST

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