TBC1D22A

Across TCGA patient cohorts, TBC1D22A mutation is significantly associated with the RNA expression of many other genes, with 2,737 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D22A-associated genes across cancer lineages are ATP5PBP7, KIF20A, and LACTB. Each is linked with TBC1D22A in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D22A-to-partner and partner-to-TBC1D22A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP5PBP7 grouped by TBC1D22A-low versus TBC1D22A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D22A→partner) and Y-score (partner→TBC1D22A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ATP5PBP7 →	+0.100	+2.809	<.001	.008	3	3
UCEC	KIF20A →	+0.676	+2.148	.001	<.001	3	3
UCEC	LACTB →	+0.375	+1.939	.003	.009	3	3
UCEC	BAG2 →	+0.736	+2.662	<.001	<.001	3	3
UCEC	CKS2 →	+0.870	+2.523	<.001	<.001	3	3
UCEC	BRIP1 →	+0.511	+2.721	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,737 associations by consensus.

ATP5PBP7 by TBC1D22A expression — SKCM

Explore this box plot interactively →