TBC1D22A

Across TCGA pan-cancer cohorts, TBC1D22A RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TBC1D22A data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher TBC1D22A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TBC1D22A expression acts as an unfavorable survival marker, although some lineages such as SCLC and ESCA show a favorable association.

SCLC, OV, and LIHC are the cancer types where TBC1D22A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	All	0.758	0.475	<.001	95	view →
OV	OS	Tertile	All	0.259	0.410	<.001	90	view →
LIHC	OS	Median	All	0.611	0.759	<.001	70	view →
ACC	DFS	Median	All	0.234	0.657	<.001	44	view →
ESCA	DFS	Median	All	0.484	0.322	.010	31	view →
UCS	OS	Tertile	IV	0.226	1.000	.036	24	view →
KIRP	OS	Median	II,III,IV	0.908	0.733	.010	21	view →
HNSC	OS	Quartile	All	0.592	0.804	.002	16	view →
CESC	OS	Tertile	II,III,IV	0.830	0.555	.023	14	view →
LUAD	OS	Quartile	All	0.133	0.549	.010	14	view →
COAD	DFS	Quartile	All	0.720	0.838	.026	8	view →
UCEC	DFS	Quartile	III,IV	0.778	0.515	.028	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TBC1D22A–SCLC (DFS)

Open the SCLC breakdown →