TBC1D22A

Across TCGA patient cohorts, TBC1D22A mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D22A-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with TBC1D22A in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D22A-to-partner and partner-to-TBC1D22A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TBC1D22A-low versus TBC1D22A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D22A→partner) and Y-score (partner→TBC1D22A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.353	+1.662	.005	.011	3	2
UCEC	EGFR_pY1068 →	-0.272	-2.000	.002	.003	3	2
UCEC	ERK2 →	+0.160	+1.700	.018	.040	3	2
UCEC	GAPDH →	+0.442	+2.000	.019	.029	3	2
COAD	PI3K-p85 →	+0.192	+2.820	.014	.035	3	1
COAD	RAD51 →	+0.201	+2.815	.020	.036	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

eEF2 by TBC1D22A expression — UCEC

Explore this box plot interactively →