TBC1D22A

Across TCGA cell cohorts, TBC1D22A mutation is significantly associated with the RNA expression of many other genes, with 328 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D22A-associated genes across cancer lineages are C10orf53, ETDC, and NPVF. Each is linked with TBC1D22A in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D22A-to-partner and partner-to-TBC1D22A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf53 grouped by TBC1D22A-low versus TBC1D22A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D22A→partner) and Y-score (partner→TBC1D22A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C10orf53 →	+0.035	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	ETDC →	+0.847	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	NPVF →	+0.014	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4D5 →	+0.014	+4.662	<.001	.005	3	1
LARGE_INTESTINE	MED26 →	+0.351	+3.212	.001	.006	3	1
LARGE_INTESTINE	RAB3A →	+0.889	+3.299	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 328 associations by consensus.

C10orf53 by TBC1D22A expression — BLOOD_Lymphoma

Explore this box plot interactively →