TBC1D2

Across TCGA patient cohorts, TBC1D2 mutation is significantly associated with the RNA expression of many other genes, with 2,935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D2-associated genes across cancer lineages are ZNF106, ARPP19, and LINC01881. Each is linked with TBC1D2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D2-to-partner and partner-to-TBC1D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF106 grouped by TBC1D2-low versus TBC1D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D2→partner) and Y-score (partner→TBC1D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF106 →	+0.427	+2.169	.001	<.001	3	3
UCEC	ARPP19 →	+0.373	+1.914	.004	<.001	3	3
UCEC	LINC01881 →	+0.286	+2.436	.002	.001	3	3
SKCM	ZBTB8A →	+0.586	+3.341	.003	.005	3	3
UCEC	MIR6894 →	+0.400	+1.496	.001	.009	3	2
SKCM	MIR5190 →	+0.181	+3.159	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,935 associations by consensus.

ZNF106 by TBC1D2 expression — UCEC

Explore this box plot interactively →