TBC1D19

Across TCGA patient cohorts, TBC1D19 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D19-associated genes across cancer lineages are INPP4B, MEK1, and Notch1. Each is linked with TBC1D19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D19-to-partner and partner-to-TBC1D19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by TBC1D19-low versus TBC1D19-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D19→partner) and Y-score (partner→TBC1D19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.337	-3.459	.003	.005	3	2
UCEC	MEK1 →	+0.327	+2.115	.013	.017	3	2
UCEC	Notch1 →	+0.143	+1.598	.004	.040	3	2
UCEC	Paxillin →	+0.255	+2.469	.006	.010	3	2
UCEC	Cyclin-B1 →	+0.600	+2.584	.002	.010	3	2
UCEC	EGFR_pY1068 →	-0.223	-2.584	.013	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

INPP4B by TBC1D19 expression — UCEC

Explore this box plot interactively →