TBC1D17

Across TCGA cell cohorts, TBC1D17 mutation is significantly associated with the mutation status of many other genes, with 3,952 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBC1D17-associated genes across cancer lineages are PLXNA2, BRINP2, and SUPT6H. Each is linked with TBC1D17 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBC1D17-to-partner and partner-to-TBC1D17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLXNA2 grouped by TBC1D17-low versus TBC1D17-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D17→partner) and Y-score (partner→TBC1D17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLXNA2 →	+2.823	+3.665	.008	.008	1	4
SKIN	BRINP2 →	+2.447	+3.647	<.001	<.001	1	4
OVARY	SUPT6H →	+4.882	+3.632	<.001	<.001	1	4
CNS	RFX1 →	+5.044	+5.614	.003	.003	1	4
CNS	ARHGEF11 →	+4.044	+5.000	.008	.008	1	4
CNS	PLXNB1 →	+4.459	+5.277	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,952 associations by consensus.

PLXNA2 by TBC1D17 expression — BLOOD_Leukemia

Explore this box plot interactively →