TBC1D15

Across TCGA patient cohorts, TBC1D15 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D15-associated genes across cancer lineages are C-Raf, MEK1, and PCNA. Each is linked with TBC1D15 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D15-to-partner and partner-to-TBC1D15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by TBC1D15-low versus TBC1D15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D15→partner) and Y-score (partner→TBC1D15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.113	+1.847	.010	.007	3	3
UCEC	MEK1 →	+0.251	+1.263	.025	.019	3	2
UCEC	PCNA →	+0.167	+1.947	.011	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.587	+1.604	.001	.010	3	2
UCEC	Caspase-8 →	-0.199	-2.221	.009	.001	3	2
UCEC	4E-BP1 →	+0.175	+1.263	.034	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

C-Raf by TBC1D15 expression — UCEC

Explore this box plot interactively →