TBC1D13

Across TCGA cell cohorts, TBC1D13 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D13-associated genes across cancer lineages are SH3GL2, PRDM7, and TKTL2. Each is linked with TBC1D13 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D13-to-partner and partner-to-TBC1D13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by TBC1D13-low versus TBC1D13-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D13→partner) and Y-score (partner→TBC1D13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.329	+3.474	<.001	.003	3	1
LARGE_INTESTINE	PRDM7 →	+0.129	+3.302	.009	.006	3	1
LARGE_INTESTINE	TKTL2 →	+0.040	+3.187	<.001	.006	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	ELOA3DP →	+0.026	+2.688	<.001	.008	3	1
LARGE_INTESTINE	CHSY3 →	+0.556	+3.252	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

SH3GL2 by TBC1D13 expression — LARGE_INTESTINE

Explore this box plot interactively →