TBC1D13

Across TCGA pan-cancer cohorts, TBC1D13 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TBC1D13’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TBC1D13 RNA is repressed in tumor relative to normal tissue. In most cancer types TBC1D13 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and HNSC are the cancer types where TBC1D13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBC1D13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.948	<.001	11	view →
KICH	Male	All	−1.278	<.001	10	view →
HNSC	All	III,IV	+0.536	<.001	10	view →
LIHC	Female	II,III,IV	+1.635	<.001	9	view →
KIRP	Female	All	−1.012	<.001	9	view →
THCA	All	All	−0.427	<.001	9	view →
BRCA	All	All	−0.600	<.001	6	view →
CHOL	All	All	+1.765	<.001	5	view →
LUAD	Female	All	−0.442	<.001	4	view →
BLCA	Male	IV	−1.487	.008	2	view →
UCEC	All	All	−0.595	.002	2	view →
STAD	All	II,III,IV	+0.455	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TBC1D13–KIRC

Open the KIRC breakdown →