TBC1D10C

Across TCGA patient cohorts, TBC1D10C mutation is significantly associated with the RNA expression of many other genes, with 1,067 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D10C-associated genes across cancer lineages are SEC61A1, UBE2K, and TFG. Each is linked with TBC1D10C in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D10C-to-partner and partner-to-TBC1D10C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC61A1 grouped by TBC1D10C-low versus TBC1D10C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D10C→partner) and Y-score (partner→TBC1D10C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SEC61A1 →	+0.444	+3.209	.004	.009	3	3
UCEC	UBE2K →	+0.583	+3.470	.001	.003	3	3
SKCM	TFG →	+0.484	+2.616	.002	.006	3	3
SKCM	GNAI3 →	+0.527	+2.667	.006	.005	3	3
UCEC	NUS1 →	+0.651	+3.480	.003	.002	3	2
UCEC	AP3S2 →	+0.417	+3.218	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,067 associations by consensus.

SEC61A1 by TBC1D10C expression — UCEC

Explore this box plot interactively →