TBC1D10C

Across TCGA pan-cancer cohorts, TBC1D10C RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TBC1D10C data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TBC1D10C RNA is associated with better overall survival. In most high-consensus cancer types, elevated TBC1D10C expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where TBC1D10C RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.431	0.284	<.001	140	view →
SKCM	OS	Median	All	0.447	0.272	<.001	121	view →
UVM	DFS	Tertile	II,III,IV	0.297	0.748	.001	77	view →
CESC	DFS	Median	All	0.823	0.656	<.001	56	view →
LGG	DFS	Median	All	0.285	0.469	<.001	45	view →
LUAD	OS	Median	All	0.857	0.767	.002	39	view →
BRCA	OS	Median	All	0.615	0.534	.001	36	view →
KIRC	DFS	Tertile	All	0.741	0.884	<.001	30	view →
GBM	OS	Quartile	All	0.241	0.587	<.001	29	view →
THYM	OS	Median	All	0.965	0.735	.004	24	view →
UCS	DFS	Tertile	IV	0.814	0.250	.024	24	view →
UCEC	OS	Tertile	IV	0.676	0.269	.011	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TBC1D10C–HNSC (OS)

Open the HNSC breakdown →