TBC1D10C

Across TCGA patient cohorts, TBC1D10C mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D10C-associated genes across cancer lineages are EGFR_pY1068, Mre11, and Rad50. Each is linked with TBC1D10C in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D10C-to-partner and partner-to-TBC1D10C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TBC1D10C-low versus TBC1D10C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D10C→partner) and Y-score (partner→TBC1D10C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.305	-3.169	.026	.020	3	1
UCEC	Mre11 →	-0.124	-3.169	.008	.020	3	1
UCEC	Rad50 →	-0.310	-3.169	.019	.020	3	1
UCEC	Smad3 →	+0.170	+3.169	.040	.019	3	1
UCEC	Cyclin-E2 →	+0.254	+3.169	.006	.020	3	1
UCEC	MEK1 →	+0.545	+3.169	.006	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

EGFR_pY1068 by TBC1D10C expression — UCEC

Explore this box plot interactively →