TBC1D10B

Across TCGA pan-cancer cohorts, TBC1D10B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TBC1D10B data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TBC1D10B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D10B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where TBC1D10B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.655	0.842	.009	18	view →
CCRCC	OS	Quartile	III,IV	0.849	0.572	.007	13	view →
UCEC	DFS	Tertile	III,IV	0.409	1.000	.016	12	view →
LSCC	DFS	Quartile	All	0.810	1.000	.022	9	view →
LUAD	OS	Median	III,IV	0.869	0.330	.006	8	view →
HNSC	OS	Median	II,III,IV	0.991	0.936	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TBC1D10B–PDAC (DFS)

Open the PDAC breakdown →