TBC1D10B

Across TCGA pan-cancer cohorts, TBC1D10B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TBC1D10B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TBC1D10B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBC1D10B is over-expressed in tumor.

HNSC, KIRP, and KIRC are the cancer types where TBC1D10B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBC1D10B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.958	<.001	12	view →
KIRP	All	IV	+1.302	<.001	11	view →
KIRC	Female	All	+0.644	<.001	11	view →
COAD	Male	III,IV	+0.535	<.001	11	view →
BLCA	All	III,IV	+0.671	<.001	10	view →
LIHC	Female	II,III,IV	+1.333	<.001	9	view →
LUAD	All	II,III,IV	+0.414	<.001	9	view →
STAD	Male	II,III,IV	+1.148	<.001	8	view →
LUSC	Female	All	+0.714	<.001	7	view →
BRCA	All	III,IV	+0.671	<.001	6	view →
CHOL	Male	All	+2.695	<.001	5	view →
ESCA	All	All	+1.016	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TBC1D10B–HNSC

Open the HNSC breakdown →