TBC1D10B

Across TCGA patient cohorts, TBC1D10B mutation is significantly associated with the RNA expression of many other genes, with 2,170 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D10B-associated genes across cancer lineages are RNA5SP411, LIN7C, and BAG3. Each is linked with TBC1D10B in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D10B-to-partner and partner-to-TBC1D10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP411 grouped by TBC1D10B-low versus TBC1D10B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D10B→partner) and Y-score (partner→TBC1D10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP411 →	+0.717	+1.656	.004	.007	3	2
UCEC	LIN7C →	+0.526	+1.947	.002	.003	3	2
UCEC	BAG3 →	+0.516	+1.925	.003	.005	3	2
UCEC	SKA1 →	+0.768	+2.332	<.001	<.001	3	2
UCEC	EXOG →	+0.377	+2.938	.001	<.001	3	2
UCEC	ABHD3 →	+0.523	+2.243	.006	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,170 associations by consensus.

RNA5SP411 by TBC1D10B expression — UCEC

Explore this box plot interactively →