TBC1D10B

Across TCGA patient cohorts, TBC1D10B mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D10B-associated genes across cancer lineages are A-Raf_pS299, JNK2, and Rad50. Each is linked with TBC1D10B in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D10B-to-partner and partner-to-TBC1D10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by TBC1D10B-low versus TBC1D10B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D10B→partner) and Y-score (partner→TBC1D10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.126	-2.459	.007	.019	3	2
UCEC	JNK2 →	+0.211	+2.331	.006	.019	3	2
UCEC	Rad50 →	-0.193	-2.000	.042	.010	3	2
UCEC	ATM →	-0.551	-1.584	.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.267	-2.700	.006	.006	3	1
UCEC	FoxM1 →	+0.250	+1.584	.014	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

A-Raf_pS299 by TBC1D10B expression — UCEC

Explore this box plot interactively →