TBC1D10B

Across TCGA cell cohorts, TBC1D10B mutation is significantly associated with the RNA expression of many other genes, with 563 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D10B-associated genes across cancer lineages are OBP2B, TMEM213, and OOSP2. Each is linked with TBC1D10B in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D10B-to-partner and partner-to-TBC1D10B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OBP2B grouped by TBC1D10B-low versus TBC1D10B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D10B→partner) and Y-score (partner→TBC1D10B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OBP2B →	+0.059	+3.544	<.001	.009	3	2
BLOOD_Leukemia	TMEM213 →	+0.097	+4.169	<.001	.003	3	2
BREAST	OOSP2 →	+0.017	+4.781	<.001	.003	3	1
BREAST	MRGPRX4 →	+0.390	+4.199	<.001	.007	3	1
BREAST	TRIM64B →	+0.166	+4.672	<.001	.002	3	1
BREAST	OR10J1 →	+0.425	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 563 associations by consensus.

OBP2B by TBC1D10B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →