TBC1D1

Across TCGA cell cohorts, TBC1D1 mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBC1D1-associated genes across cancer lineages are CBLIF, PRAMEF18, and OR12D2. Each is linked with TBC1D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D1-to-partner and partner-to-TBC1D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBLIF grouped by TBC1D1-low versus TBC1D1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D1→partner) and Y-score (partner→TBC1D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CBLIF →	+0.024	+3.947	<.001	.004	3	2
SKIN	PRAMEF18 →	+0.005	+4.415	<.001	<.001	3	2
URINARY_TRACT	OR12D2 →	+0.102	+4.087	.002	.009	3	1
STOMACH	SPINK14 →	+0.433	+5.285	<.001	.003	3	1
LARGE_INTESTINE	GCAT →	+1.107	+3.321	.002	.003	3	1
LARGE_INTESTINE	GABRE →	-1.524	-2.541	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

CBLIF by TBC1D1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →