TAZ

Across TCGA patient cohorts, TAZ mutation is significantly associated with the RNA expression of many other genes, with 1,193 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAZ-associated genes across cancer lineages are MAP1LC3P, RNU6-1318P, and IGHD6-19. Each is linked with TAZ in more than 2 cancer types. Because this analysis shows association rather than direction, both TAZ-to-partner and partner-to-TAZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP1LC3P grouped by TAZ-low versus TAZ-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAZ→partner) and Y-score (partner→TAZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	MAP1LC3P →	+0.216	+3.320	<.001	.008	3	3
UCEC	RNU6-1318P →	+0.292	+3.078	<.001	<.001	3	2
UCEC	IGHD6-19 →	+0.532	+2.835	<.001	<.001	3	2
UCEC	ANTXRLP1 →	+0.080	+1.917	.002	.006	3	1
UCEC	MIR4494 →	+0.130	+3.242	<.001	.003	3	1
UCEC	MIR4539 →	+0.708	+1.789	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,193 associations by consensus.

MAP1LC3P by TAZ expression — BLCA

Explore this box plot interactively →