TAX1BP1

Across TCGA cell cohorts, TAX1BP1 mutation is significantly associated with the RNA expression of many other genes, with 163 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAX1BP1-associated genes across cancer lineages are PFN3, SH3GL2, and GRPEL1. Each is linked with TAX1BP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAX1BP1-to-partner and partner-to-TAX1BP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFN3 grouped by TAX1BP1-low versus TAX1BP1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAX1BP1→partner) and Y-score (partner→TAX1BP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PFN3 →	+0.057	+4.450	<.001	.004	3	2
LARGE_INTESTINE	SH3GL2 →	+1.074	+2.667	.001	.007	3	1
LARGE_INTESTINE	GRPEL1 →	+0.529	+2.451	.001	.009	3	1
LARGE_INTESTINE	DDX25 →	+0.070	+3.769	<.001	<.001	3	1
LARGE_INTESTINE	MRPL3 →	+0.314	+2.451	.006	.009	3	1
LARGE_INTESTINE	ATP5PB →	+0.506	+3.502	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 163 associations by consensus.

PFN3 by TAX1BP1 expression — OVARY

Explore this box plot interactively →