Across TCGA patient cohorts, TAT mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAT-associated genes across cancer lineages are mTOR_pS2448, Notch1, and PDCD4. Each is linked with TAT in more than 1 cancer types. Because this analysis shows association rather than direction, both TAT-to-partner and partner-to-TAT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAT→partner) and Y-score (partner→TAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.133	-1.680	.017	.042	3	2
UCEC	Notch1 →	+0.223	+2.713	<.001	.003	3	2
UCEC	PDCD4 →	-0.499	-1.765	.004	.014	3	2
UCEC	TFRC →	+0.561	+2.000	.004	.030	3	2
UCEC	ATM →	-0.482	-2.000	.004	.030	3	2
UCEC	Caveolin-1 →	-0.659	-2.584	.015	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

TAT survival (RNA) · tumor vs normal (RNA) · all TAT data types