TASOR2

Across TCGA patient cohorts, TASOR2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TASOR2-associated genes across cancer lineages are AMPK_pT172, STAT3_pY705, and MIG-6. Each is linked with TASOR2 in more than 4 cancer types. Because this analysis shows association rather than direction, both TASOR2-to-partner and partner-to-TASOR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AMPK_pT172 grouped by TASOR2-low versus TASOR2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TASOR2→partner) and Y-score (partner→TASOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	AMPK_pT172 →	-0.304	-3.309	.048	.009	3	5
UCEC	STAT3_pY705 →	-0.315	-1.502	<.001	<.001	3	4
COAD	MIG-6 →	+0.096	+3.229	.049	.009	3	4
COAD	ASNS →	+0.723	+3.178	<.001	.010	3	3
COAD	4E-BP1 →	+0.285	+3.178	.008	.010	3	3
UCEC	RAD51 →	+0.094	+1.289	.011	.021	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

AMPK_pT172 by TASOR2 expression — BLCA

Explore this box plot interactively →