TASOR2

Across TCGA pan-cancer cohorts, TASOR2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of TASOR2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TASOR2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TASOR2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and STAD are the cancer types where TASOR2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TASOR2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.926	<.001	11	view →
BLCA	All	All	+0.643	.001	10	view →
STAD	Male	II,III,IV	+1.146	<.001	9	view →
KIRC	All	All	+0.422	<.001	9	view →
LIHC	All	II,III,IV	+0.922	<.001	8	view →
THCA	All	II,III,IV	−0.678	<.001	8	view →
LUSC	Male	II,III,IV	+0.913	<.001	7	view →
LUAD	Male	All	+0.846	<.001	7	view →
KIRP	All	II,III,IV	+0.598	.006	7	view →
COAD	Male	All	+0.581	<.001	7	view →
BRCA	All	All	+0.807	<.001	6	view →
CHOL	Male	All	+2.133	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

TASOR2–HNSC

Open the HNSC breakdown →