TAS2R8

Across TCGA pan-cancer cohorts, TAS2R8 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TAS2R8 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TAS2R8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TAS2R8 expression acts as an unfavorable survival marker.

KIRC, READ, and SCLC are the cancer types where TAS2R8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.181	0.805	.002	21	view →
READ	OS	Median	II,III,IV	0.054	0.934	<.001	18	view →
SCLC	DFS	Median	II,III,IV	0.137	0.602	.008	18	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TAS2R8–KIRC (OS)

Open the KIRC breakdown →