TAS2R8

Across TCGA patient cohorts, TAS2R8 mutation is significantly associated with the RNA expression of many other genes, with 2,064 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R8-associated genes across cancer lineages are RN7SKP135, ACTG1P13, and MIR7702. Each is linked with TAS2R8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAS2R8-to-partner and partner-to-TAS2R8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP135 grouped by TAS2R8-low versus TAS2R8-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R8→partner) and Y-score (partner→TAS2R8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RN7SKP135 →	+0.219	+5.105	.009	.008	3	3
HNSC	ACTG1P13 →	+0.058	+5.435	<.001	.005	3	2
UCEC	MIR7702 →	+0.171	+3.812	<.001	.008	3	2
BLCA	RNU6ATAC29P →	+0.777	+5.038	<.001	.009	3	2
BLCA	LINC02543 →	+0.123	+5.685	<.001	.003	3	2
BLCA	KRTAP21-4P →	+0.064	+6.814	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,064 associations by consensus.

RN7SKP135 by TAS2R8 expression — STAD

Explore this box plot interactively →