TAS2R8

Across TCGA patient cohorts, TAS2R8 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R8-associated genes across cancer lineages are eEF2, A-Raf_pS299, and PCNA. Each is linked with TAS2R8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R8-to-partner and partner-to-TAS2R8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TAS2R8-low versus TAS2R8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R8→partner) and Y-score (partner→TAS2R8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.361	+2.999	.012	.035	3	2
UCEC	A-Raf_pS299 →	-0.097	-2.321	.044	.034	3	2
UCEC	PCNA →	+0.212	+3.169	.014	.018	3	2
UCEC	Bax →	+0.242	+1.906	.012	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.634	+3.604	.007	.001	3	2
UCEC	14-3-3_beta →	-0.096	-2.432	.017	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

eEF2 by TAS2R8 expression — UCEC

Explore this box plot interactively →