TAS2R8

Across TCGA cell cohorts, TAS2R8 RNA expression is significantly associated with the go_rna of many other GO terms, with 590 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TAS2R8-associated GO terms across cancer lineages are Regulation of RNA splicing, Regulation of double-strand break repair, and Sensory perception of mechanical stimulus. Each is linked with TAS2R8 in more than 4 cancer types. Because this analysis shows association rather than direction, both TAS2R8-to-partner and partner-to-TAS2R8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of RNA splicing grouped by TAS2R8-low versus TAS2R8-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R8→partner) and Y-score (partner→TAS2R8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of RNA splicing →	+0.056	+0.056	.002	.009	2	5
BLOOD_Leukemia	Regulation of double-strand break repair →	+0.034	+0.013	.001	.008	3	4
LARGE_INTESTINE	Sensory perception of mechanical stimulus →	-0.054	-0.012	.005	.007	3	4
OVARY	mRNA 5'-splice site recognition →	+0.065	+0.025	.007	.008	3	3
OVARY	Negative regulation of Notch signaling pathway →	+0.051	+0.025	.005	.006	3	3
LARGE_INTESTINE	Positive regulation of mRNA 3'-end processing →	+0.061	+0.013	.008	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 590 associations by consensus.

Regulation of RNA splicing by TAS2R8 expression — LUNG_SCLC

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