TAS2R8

Across TCGA cell cohorts, TAS2R8 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAS2R8-associated genes across cancer lineages are FAM71B, TEX26, and PATE4. Each is linked with TAS2R8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R8-to-partner and partner-to-TAS2R8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM71B grouped by TAS2R8-low versus TAS2R8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R8→partner) and Y-score (partner→TAS2R8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM71B →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TEX26 →	+0.039	+3.684	<.001	.006	3	1
LARGE_INTESTINE	PATE4 →	+0.034	+4.510	<.001	.001	3	1
LARGE_INTESTINE	OR6Q1 →	+0.018	+4.437	<.001	.004	3	1
SKIN	MINAR2 →	+0.013	+4.977	<.001	.007	3	1
OVARY	KRTAP1-1 →	+0.071	+4.450	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

FAM71B by TAS2R8 expression — LARGE_INTESTINE

Explore this box plot interactively →