TAS2R8

Across TCGA cell cohorts, TAS2R8 mutation is significantly associated with the mutation status of many other genes, with 747 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAS2R8-associated genes across cancer lineages are TNFAIP6, SNX8, and MAK. Each is linked with TAS2R8 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAS2R8-to-partner and partner-to-TAS2R8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TNFAIP6 grouped by TAS2R8-low versus TAS2R8-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R8→partner) and Y-score (partner→TAS2R8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	TNFAIP6 →	+4.239	+5.053	.007	.007	1	3
SKIN	SNX8 →	+4.239	+5.053	.007	.007	1	2
SKIN	MAK →	+4.824	+5.392	.004	.004	1	2
SKIN	SMAD9 →	+4.239	+5.053	.007	.007	1	2
SKIN	CRISPLD1 →	+4.824	+5.392	.004	.004	1	2
OVARY	SLC6A13 →	+4.977	+4.415	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 747 associations by consensus.

TNFAIP6 by TAS2R8 expression — SKIN

Explore this box plot interactively →