Across TCGA patient cohorts, TAS2R60 mutation is significantly associated with the RNA expression of many other genes, with 3,156 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R60-associated genes across cancer lineages are GUF1, LRRC58, and SUGT1. Each is linked with TAS2R60 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAS2R60-to-partner and partner-to-TAS2R60 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R60→partner) and Y-score (partner→TAS2R60) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GUF1 →	+0.485	+3.346	.002	.005	3	3
UCEC	LRRC58 →	+0.626	+2.818	.003	.001	3	3
UCEC	SUGT1 →	+0.436	+2.807	.005	.003	3	3
UCEC	SARS1 →	+0.515	+3.939	.001	<.001	3	3
UCEC	MPP5 →	+0.741	+3.928	<.001	<.001	3	3
COAD	RNU6-1305P →	+2.239	+6.122	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,156 associations by consensus.

Exploration

TAS2R60 survival (RNA) · tumor vs normal (RNA) · all TAS2R60 data types