Across TCGA pan-cancer cohorts, TAS2R60 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated TAS2R60 data layer compared with 4 for mutation status.
The strongest signal is observed in esophageal carcinoma (ESCA), where higher TAS2R60 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TAS2R60 expression acts as an unfavorable survival marker, although some lineages such as ESCA and HNSC show a favorable association.
ESCA, LGG, and UCEC are the cancer types where TAS2R60 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.