Across TCGA patient cohorts, TAS2R50 mutation is significantly associated with the RNA expression of many other genes, with 2,486 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R50-associated genes across cancer lineages are RN7SL868P, NUDT4P2, and RNA5SP406. Each is linked with TAS2R50 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R50-to-partner and partner-to-TAS2R50 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R50→partner) and Y-score (partner→TAS2R50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL868P →	+0.167	+5.038	.004	.009	3	2
UCEC	NUDT4P2 →	+0.039	+2.397	<.001	.009	3	2
HNSC	RNA5SP406 →	+0.338	+7.954	<.001	.008	3	2
UCEC	RNA5SP407 →	+0.218	+2.764	<.001	.003	3	2
HNSC	RNU6-1244P →	+0.347	+7.954	<.001	.008	3	1
BLCA	RPL5P19 →	+0.153	+5.329	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,486 associations by consensus.

Exploration

TAS2R50 survival (RNA) · tumor vs normal (RNA) · all TAS2R50 data types