Across TCGA patient cohorts, TAS2R50 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R50-associated genes across cancer lineages are EGFR, eIF4G, and FoxM1. Each is linked with TAS2R50 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R50-to-partner and partner-to-TAS2R50 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R50→partner) and Y-score (partner→TAS2R50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.198	-2.321	.002	.034	3	1
UCEC	eIF4G →	+0.284	+1.906	.023	.016	3	1
UCEC	FoxM1 →	+0.294	+2.469	.004	.010	3	1
UCEC	INPP4B →	-0.335	-3.459	.010	.005	3	1
UCEC	JNK2 →	+0.170	+2.331	.034	.019	3	1
UCEC	Notch1 →	+0.179	+1.906	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

TAS2R50 survival (RNA) · tumor vs normal (RNA) · all TAS2R50 data types