Across TCGA patient cohorts, TAS2R46 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R46-associated genes across cancer lineages are MTND3P16, MIR2114, and RNU4-58P. Each is linked with TAS2R46 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R46-to-partner and partner-to-TAS2R46 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R46→partner) and Y-score (partner→TAS2R46) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTND3P16 →	+0.123	+4.137	<.001	.008	3	2
COAD	MIR2114 →	+0.244	+7.741	.001	.009	3	2
UCEC	RNU4-58P →	+0.317	+3.396	<.001	.006	3	1
UCEC	RNU6-1155P →	+0.221	+5.475	<.001	.001	3	1
UCEC	MIR629 →	+0.313	+3.997	<.001	.009	3	1
UCEC	IGKV1D-42 →	+0.797	+3.606	.007	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

Exploration

TAS2R46 survival (RNA) · tumor vs normal (RNA) · all TAS2R46 data types