Across TCGA patient cohorts, TAS2R42 mutation is significantly associated with the RNA expression of many other genes, with 948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R42-associated genes across cancer lineages are GXYLT1P2, RNU4-45P, and OR2T5. Each is linked with TAS2R42 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R42-to-partner and partner-to-TAS2R42 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R42→partner) and Y-score (partner→TAS2R42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	GXYLT1P2 →	+0.042	+5.103	<.001	.008	3	2
COAD	RNU4-45P →	+0.538	+7.741	<.001	.009	3	2
COAD	OR2T5 →	+0.209	+7.741	<.001	.009	3	2
COAD	RNU6-1139P →	+0.401	+7.741	<.001	.009	3	2
LUAD	MTND4P28 →	+0.101	+5.197	<.001	.003	3	2
LUAD	UGT2A3P7 →	+0.178	+4.268	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 948 associations by consensus.

Exploration

TAS2R42 survival (RNA) · tumor vs normal (RNA) · all TAS2R42 data types