Across TCGA cell cohorts, TAS2R41 mutation is significantly associated with the mutation status of many other genes, with 2,447 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAS2R41-associated genes across cancer lineages are CLINT1, PLB1, and SYNPO2. Each is linked with TAS2R41 in more than 3 cancer types. Because this analysis shows association rather than direction, both TAS2R41-to-partner and partner-to-TAS2R41 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R41→partner) and Y-score (partner→TAS2R41) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CLINT1 →	+5.392	+4.824	.004	.004	1	4
SKIN	PLB1 →	+2.807	+4.247	.007	.007	1	4
SOFT_TISSUE	SYNPO2 →	+5.066	+4.502	.007	.007	1	4
SOFT_TISSUE	RTEL1 →	+5.066	+4.502	.007	.007	1	3
SOFT_TISSUE	PLXNA4 →	+3.329	+4.562	.003	.003	1	3
SOFT_TISSUE	GAS2L2 →	+5.066	+4.502	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,447 associations by consensus.

Exploration

TAS2R41 survival (RNA) · tumor vs normal (RNA) · all TAS2R41 data types