TAS2R4

Across TCGA patient cohorts, TAS2R4 mutation is significantly associated with the RNA expression of many other genes, with 2,273 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R4-associated genes across cancer lineages are RNU4-58P, RNA5SP414, and RNA5SP411. Each is linked with TAS2R4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R4-to-partner and partner-to-TAS2R4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by TAS2R4-low versus TAS2R4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R4→partner) and Y-score (partner→TAS2R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU4-58P →	+0.214	+4.385	<.001	.008	3	2
UCEC	RNA5SP414 →	+0.831	+2.840	<.001	<.001	3	2
UCEC	RNA5SP411 →	+1.557	+2.808	<.001	<.001	3	2
UCEC	RNA5SP419 →	+0.956	+2.661	<.001	.001	3	2
UCEC	RNA5SP408 →	+0.349	+2.865	<.001	.004	3	2
UCEC	RNA5SP422 →	+1.011	+2.256	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,273 associations by consensus.

RNU4-58P by TAS2R4 expression — SKCM

Explore this box plot interactively →