TAS2R39

Across TCGA cell cohorts, TAS2R39 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TAS2R39-associated genes across cancer lineages are PAX4, FAM205C, and IRS4. Each is linked with TAS2R39 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R39-to-partner and partner-to-TAS2R39 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAX4 grouped by TAS2R39-low versus TAS2R39-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R39→partner) and Y-score (partner→TAS2R39) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PAX4 →	+0.022	+4.930	<.001	.008	3	1
SOFT_TISSUE	FAM205C →	+0.105	+4.930	<.001	.008	3	1
LARGE_INTESTINE	IRS4 →	+0.352	+4.196	<.001	.002	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
SKIN	CLEC4C →	+0.054	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PAX4 by TAS2R39 expression — SOFT_TISSUE

Explore this box plot interactively →