TAS1R2

Across TCGA patient cohorts, TAS1R2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS1R2-associated genes across cancer lineages are ATM, PCNA, and 4E-BP1. Each is linked with TAS1R2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAS1R2-to-partner and partner-to-TAS1R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TAS1R2-low versus TAS1R2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS1R2→partner) and Y-score (partner→TAS1R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.549	-1.999	<.001	<.001	3	3
UCEC	PCNA →	+0.186	+2.807	.004	.002	3	3
UCEC	4E-BP1 →	+0.286	+2.277	<.001	<.001	3	3
STAD	eIF4E →	+0.161	+3.459	.048	.005	3	2
STAD	YB-1_pS102 →	+0.142	+3.459	.021	.005	3	2
STAD	Bad_pS112 →	-0.298	-3.438	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

ATM by TAS1R2 expression — UCEC

Explore this box plot interactively →