TAS1R2

Across TCGA pan-cancer cohorts, TAS1R2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated TAS1R2 data layer compared with 11 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher TAS1R2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TAS1R2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CESC show a favorable association.

KIRP, DLBC, and LUAD are the cancer types where TAS1R2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.762	0.961	<.001	78	view →
DLBC	DFS	Tertile	All	0.338	0.795	.010	76	view →
LUAD	OS	Tertile	All	0.782	0.317	.006	30	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	27	view →
CESC	OS	Tertile	All	0.972	0.852	.014	24	view →
LIHC	OS	Tertile	All	0.644	0.801	.003	24	view →
KIRC	DFS	Quartile	II,III,IV	0.238	0.560	.027	20	view →
PRAD	OS	Tertile	All	0.948	0.997	.001	12	view →
ACC	DFS	Tertile	II,III,IV	0.280	0.576	.024	9	view →
THYM	OS	Tertile	All	0.866	0.984	.043	9	view →
PCPG	DFS	Tertile	All	0.535	0.935	.048	9	view →
HNSC	DFS	Tertile	II,III,IV	0.370	0.579	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

TAS1R2–KIRP (OS)

Open the KIRP breakdown →